PUBLICATION ON “Associations between treatments, comorbidities and multidimensional aspects of quality of life among patients with advanced cancer in the Netherlands—a 2017–2020 multicentre cross‑sectional study”

Posted July 14, 2023

Abstract

To investigate associations between quality of life (QoL) and 1) immunotherapy and other cancer treatments

received three months before QoL measurements, and 2) the comorbidities at the time of completion or in the year prior to

QoL measurements, among patients with advanced cancer.

Methods A cross-sectional study is conducted on patients with advanced cancer in the Netherlands. The data come from the

baseline wave of the 2017–2020 eQuiPe study. Participants were surveyed via questionnaires (including EORTC QLQ-C30).

Using multivariable linear and logistic regression models, we explored statistical associations between QoL components

and immunotherapy and other cancer treatments as well as pre-existing comorbidities while adjusting for age, sex, socioeconomic

status.

Of 1088 participants with median age 67 years, 51% were men. Immunotherapy was not associated with global

QoL but was associated with reduced appetite loss (odds ratio (OR) = 0.6, 95%CI = [0.3,0.9]). Reduced global QoL was

associated with chemotherapy (adjusted mean difference (β) = − 4.7, 95% CI [− 8.5,− 0.8]), back pain (β = − 7.4, 95% CI

[− 11.0,− 3.8]), depression (β = − 13.8, 95% CI [− 21.5,− 6.2]), thyroid diseases (β = − 8.9, 95% CI [− 14.0,− 3.8]) and

diabetes (β = − 4.5, 95% CI [− 8.9,− 0.5]). Chemotherapy was associated with lower physical (OR = 2.4, 95% CI [1.5,3.9])

and role (OR = 1.8, 95% CI [1.2,2.7]) functioning, and higher pain (OR = 1.9, 95% CI [1.3,2.9]) and fatigue (OR = 1.6, 95%

CI [1.1,2.4]).

Our study identified associations between specific cancer treatments, lower QoL and more symptoms. Monitoring

symptoms may improve QoL of patients with advanced cancer. Producing more evidence from real life data would help

physicians in better identifying patients who require additional supportive care.